Cold Plasma Created by Helium Compared to Air

Both ozone cold plasma and helium cold plasma are types of non-thermal plasmas. These plasmas exist at room temperature, which makes them suitable for a variety of medical, industrial, and environmental applications without causing damage to materials that are sensitive to heat. The key difference between them lies in their composition, properties, and the types of treatments they are used for.

Ozone Cold Plasma

Ozone cold plasma (often referred to as ozone-based plasma or ozone plasma) is a form of cold plasma where ozone (O₃) is generated and introduced into the plasma environment. The ozone molecules are generated from the oxygen present in the air by ionization processes, which involve breaking down oxygen molecules (O₂) into free radicals, and some of these radicals combine to form ozone (O₃).

Technology Behind Ozone Cold Plasma:

Plasma Generation: Ozone cold plasma is created by applying a high voltage to a gas, typically air, which results in ionization. The gas turns into plasma, with highly energetic particles like electrons, ions, and free radicals, including ozone molecules.  This cold plasma only needs the air to treat.

Generation of Ozone: When oxygen molecules (O₂) in the air interact with the energetic particles from the plasma, ozone (O₃) is produced. This ozone is then present in the cold plasma, adding to its reactivity and biological effects.

Low Temperature: The plasma itself remains at a relatively low temperature despite the high energy levels of the ions and electrons, which means it can be used in environments that require temperature control, such as medical devices or delicate materials.

Applications of Ozone Cold Plasma:

Wound Healing: Ozone cold plasma has antimicrobial properties, making it effective in treating infected or non-healing wounds. The reactive species generated by the plasma can kill bacteria, viruses, and fungi.

Disinfection: It is used for surface sterilization in medical instruments, hospital environments, and even food safety applications by killing pathogens.  

Skin Rejuvenation: In cosmetic dermatology, ozone cold plasma can be used to promote collagen production and rejuvenate the skin by triggering a controlled oxidative stress response in the skin cells.

Helium Cold Plasma

Helium cold plasma is another type of non-thermal plasma, but it uses helium gas instead of air. Helium is an inert gas, which means it does not react as easily with other substances compared to oxygen. This makes helium cold plasma useful in applications where a more controlled, gentle form of plasma is needed without the formation of reactive molecules like ozone.  This cold plasma needs helium to treat.

Technology Behind Helium Cold Plasma:

Plasma Generation: Similar to ozone plasma, helium cold plasma is generated by ionizing helium gas. This is achieved by applying an electric field or a high-voltage current to the gas, creating a plasma consisting of electrons, ions, and excited atoms of helium.

No Ozone Production: Since helium is inert and does not react to form ozone like oxygen, the plasma generated from helium is less reactive, making it more suitable for applications where controlled or minimal chemical interactions are required.

Low Temperature: The plasma is still non-thermal, meaning it is cool enough to treat sensitive materials without causing thermal damage.

Applications of Helium Cold Plasma:

Skin Treatment: Helium cold plasma is often used in dermatology for its ability to treat acne, reduce inflammation, and improve skin texture by stimulating cellular processes like collagen synthesis.

Wound Healing: Like ozone plasma, helium cold plasma can also promote wound healing by increasing the rate of tissue regeneration and reducing infection risk.

Sterilization: He-plasma is used in sterilizing medical instruments, especially in delicate settings where non-reactive and low-risk conditions are needed.

Cancer Treatment: Research suggests that helium plasma may induce cancer cell apoptosis (programmed cell death) in certain types of cancer.

Device	Gas Used	Plasma Type	Treatment Depth	Best Uses
Cool Jet Plasma	Air-Based (O₂ & N₂)	Cold Atmospheric Plasma (CAP)	Superficial & Medium Depth	Acne, rosacea, wound healing, anti-inflammatory
Jet Plasma (e.g., Profosma, Jet Plasma Pro)	Air-Based (O₂ & N₂)	High-Frequency Cold Plasma	Deep Penetration (Dermis & SMAS)	Skin tightening, collagen remodeling, hyperpigmentation
Plaxel Plus Cold Plasma	Air-Based (O₂ & N₂)	Cold Plasma Arc with Electroporation	Superficial	Gentle skin resurfacing, anti-aging, brightening
Helium Cold Plasma	Helium Gas	Plasma Energy with Thermal Effect	Deepest Penetration (Subdermal & SMAS)	Skin tightening, deep wrinkle reduction, surgical applications

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